HCC and liver disease risks in homozygous PNPLA3 p.I148M carriers approach monogenic inheritance

Reply to: HCC and liver disease risk in homozygous PNPLA3 p.I148M carriers approach monogenic inheritance.

PNPLA3 I148M polymorphism and progressive liver disease.

The 148 Isoleucine to Methionine protein variant (I148M) of patatin-like phospholipase domain-containing 3 (PNPLA3), a protein is expressed in the liver and is involved in lipid metabolism, has recently been identified as a major determinant of liver fat content. Several studies confirmed that the I148M variant predisposes towards the full spectrum of liver damage associated with fatty liver: f...

Difference Between Monogenic and Polygenic Inheritance

Inheritance is the process where genetic information is transferred from the parent to offspring. The information that is transferred is stored in genes, which are Deoxyribose Nucleic Acid (DNA)fragments that codes for specific proteins that are functional and could be transferred. Each gene consists of a pair of alleles that determine the character and as Mendelian Genetics suggests, these all...

Nonalcoholic fatty liver disease and the PNPLA3 gene.

Nonalcoholic fatty liver disease, a potentially fatal obesity-related condition, affects more than 70 million people in the United States. Nurses are well-positioned to impact this genetically influenced disease by is increasing awareness, providing patient education, and advocating for affected persons.

HBsAg carriers with and without liver disease

Hepatitis B virus (HBV) is a major cause of chronic liver disease in southern Italy. In the same area superinfection with the delta agent is endemic. To assess the prevalence of delta infection in a large population of patients with acute and chronic HBV related liver disease and to look for differential features among delta infected and uninfected subjects sera from 592 consecutive HBsAg posit...